A study on the performance of lettuce to different sources of organic fertilizers was conducted from February 2019 to March 2019 at St.lgnatius, Pandan, Angeles City. The experiment was laid out following the Randomized Complete Block Design (RCBD) and replicated three times. The treatments were as follows: T1 - Control, T2 - Fermented Plant Juice, T3 - Goat Manure Solution, and T4 - Fish Amino Acid Based on the results of the study, the different sources of organic fertilizers did not Significantly affect lettuce on all the parameters evaluated such as: plant height, length of the longest leaves per plant, number of leaves per plant, weight of plants, number of marketable and non-marketable plants, computed yield in 1000 m2 and cost and return analysis. However, in terms of cost and return analysis, T3 (Goat Manure Solution) produced the highest ROI with 82.23.