Due to the negative impacts on numerous industries around the world, the environmental contamination brought on by non-essential heavy metals has been of significant concern and has now become an issue. The utilization of plants in the bioremediation of heavy metals to treat contaminated soil is more common. Thus, the primary objective of this research was to develop and assess an integrated-ecological approach efficacy in remediating Pb-contaminated soil using cow manure, earthworm, and mustard. ICP-AES was used to detect the lead concentrations m mustard, earthworm, and soil samples from three different treatments. Results showed that the combination of cow manure and earthworm positively affects mustard's growth and development, increasing its biomass, resulting in increased mustard lead accumulating efficiency. It turned out that by using amendments, hyper-accumulating plants like mustard may withstand the toxicity of heavy metals. Exposure to heavy metal pollutants may cause toxicity and human health problems. Thus, a health risk assessment in mustard accumulated Pb was carried out. Results indicate that eating mustard from 400ppm lead contaminated soil could cause human health problems. Hence, this suggests that the mustard or any edible crops used for phytoremediation must not be used for human or animal consumption. Keywords: earthworm, heavy metal, hyper-accumulating, lead, mustard, phytoextraction.