This study was conducted at the Bioresource Processing Center of the College of Engineering and Computer Studies (CoECS), Pampanga State Agricultural University, PAC Magalang, Pampanga, from April to July 2022. It aimed to establish the spray drying characteristics of mulberry leaves. Parameters such as decoction ratio of 1:5 (leaves and water) and temperature of 85°C and 90°C, with two different methods of boiling and blanching and 15% maltodextrin by weight on the variables namely drying capacity, moisture content, and recovery rate, were evaluated. Results showed that the temperature and two different methods in all treatments were not significant in terms of drying capacity and moisture content. In contrast, a comparison among treatments using the least significant difference test revealed that A2B2 (90°C, blanching method, 15% maltodextrin) was found significant at 5% LSD test while A1B1 (85°C, boiling method, 15% maltodextrin), A1B2 (90°C, boiling method, 15% maltodextrin), and A2B1 (85°C, blanching method, 15% maltodextrin) were not found significant at 5% LSD test. In sensory evaluation revealed that in terms of color, aroma, and taste, analysis of variance results showed that there is no significant difference, respectively. But the general acceptability showed that treatments were highly significant at 1% level. This means that a comparison among treatment reveals that A2B2 was generally acceptable to panelist. In addition, A2B2 obtained the top setting for temperature, this was observed from A2B2 with an inlet temperature range of 190°C - 270 °C, and recovery rate of 1.083 kg/hr, moisture content of 6.83%, and with a drying capacity of 10.22 kg/hr. For nutrient analysis, A2B2 was also the best treatment and the results showed that spray dried mulberry leaf powder has 3.51% crude protein and 1.99% ash content. The recovery rate, moisture content, and drying capacity were calculated mathematically using the linear regression approach, which produced the equations DC = 11.94 - 1.5RR + 0.015MC for the values used in this study. The computation for the mathematical model yielded a success rate of 96.93%.