The study was carried out to determine the reproductive and litter performance of upgraded New Zealand White rabbit bred at pre-weaning. Eight apparently healthy, nulliparous upgraded New Zealand White does were equally and randomly divided into two groups. Group A were mated seven days after weaning whereas Group B were mated seven days before weaning. Data obtained were body condition score and weight of does at mating, kindling and weaning; litter size and weight; and mortality and morbidity rate at days 7 and 35 (weaning). Data were analyzed using independent samples t test. The results revealed that body weight of does in Group A at kindling and weaning (2.51 and 2.55, respectively) were significantly higher (P<0.05) than in Group B (2.31 and 2.33, respectively). Gestation length (in days) was also significantly shorter (P<0.05) in Group A (32.25) as compared to Group B (33.33) while other data were statistically comparable (P>0.05). Based on the results of the study, it can be concluded that pre-weaning mating and the standard post-weaning breeding can result to comparable reproductive and litter performance which can increase productivity of the farm. Pasion Weelen O. 2022. Reproductive and litter performance of upgraded New Zealand White rabbit at pre-weaning breeding. College of Veterinary Medicine, Pampanga State Agricultural University. Undergraduate Thesis Adviser: Rogelio P. Carandang Jr., DVM, PhD.