ABSTRACT This study profiled canine parvovirus (CPV) cases in selected veterinary clinics in Mexico, Pampanga for the months of January to December 2021 in terms of demographics (sex, age, breed, and vaccination status), disease characteristics (clinical signs, treatment, status of the animal), spatial (per barangay) and temporal (per month) distribution. Association of CPV cases to animal demographics and animal status to treatment were determined by Pearson's Chi-Square test; major contributors to the association and the strength of association were identified with adjusted residual and Phi & Crammer's V. Results showed that among the 211 dogs tested for CPV, 71% tested positive, 46% of which were male dogs, 62% were puppies (6 months and below), Shih Tzu (24%) was the common breed infected, were unvaccinated (48%), and the majority of cases (57%) were observed during summer (Dec-May) mostly from Brgy. Pandacaqui (41%). Statistical analysis showed that among the categorical variables, only the age group was found to have a significant association with CPV cases. Among the treatments given, antiemetics and antibiotics had statistical association to animal status while IV fluids and vitamins/supplements had a highly significant association; antidiarrheals showed no significant association (p<0.05). Capati, Alliza Faith T. 2022. A Retrospective study on canine parvovirus cases from selected veterinary clinics in Mexico, Pampanga. College of Veterinary Medicine, Pampanga State Agricultural University, Magalang, Pampanga, Undergraduate Thesis Adviser: Sarah Jane P. Tiangco, DVM