Depression is the truly leading cause of ill health and disability worldwide and it affects also the academe. The teaching profession is one of the most stressful work and stress on teaching is continously growing. Thus, this research intended to determine the perceptions of faculty members of Pampanga State Agricultural University on depression. Through a survey, 90 faculty members in PSAU participated in the study. Data was analyzed through frequency, mean and chi square. Most of the respondents are female, Roman Catholic, married, with units in doctorate and are 0-9 years in service. The respondents' perceived susceptibility on depression is anchored on the concepts that having strong faith in God, strong family support and handling stress can prevent a person to be affected by depression. In terms of perceived severity, respondents believe that depression affects work performance, physical health and social life. On the other hand, the respondents' perceived benefits on taking actions to avoid depression such as having family support and understanding, and talking about one's depression openly are significant on coping with depression. For the perceived barriers, respondents believed that people are not aware that depression is a mental health condition, the lack of institutional support programs on depression and the denial among the depressed. For the correlation, the respondents' civil status and the perceived benefits are significantly related. Also, the respondents' length of service and the perceived susceptibility are significantly related as well as their perceived barriers. For the recommended practices, respondents believe that not hiding the condition and seeking family support, thinking positive by counting blessings and staying healthy by exercising and eating nutritious foods can be done to handle with depression. The researcher suggest that PSAU administration should establish a program which can help the stakeholders and members of the university to understand mental health concerns and issues.